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Tell your doctor if you do not take your medication. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
The dose of Ivermectin Topical Application will be different for different patients. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of Ivermectin Topical Application that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Ivermectin is well tolerated compared to other microfilaricidal agents i. Adverse reactions i. Adverse effects tend to occur with lesser frequency during periods of retreatment.
Ivermectin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:. If you are taking ivermectin to treat onchocerciasis, you may also experience the following side effects.
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:.
Ivermectin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Some side effects of ivermectin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
Loss of vision has occurred rarely but usually resolved without corticosteroid treatment. Conjunctival hemorrhage has been reported during postmarketing experience in patients treated for onchocerciasis.
Worsening of Mazzotti reactions, including arthralgia, synovitis, lymph node enlargement and tenderness, pruritus, skin involvement including edema, papular and pustular or frank urticarial rash , and fever, has been reported during the first 4 days following treatment for onchocerciasis.
Nervous system side effects have included dizziness, headache, somnolence, vertigo, and tremor. Serious or fatal encephalopathy has been reported rarely in patients with onchocerciases, and heavily infected with Loa loa, either spontaneously or after treatment with ivermectin.
Seizures have been reported during postmarketing experience. Gastrointestinal side effects have included anorexia, constipation, diarrhea, nausea, vomiting, and abdominal distention.
Other side effects have included asthenia, fatigue, abdominal pain, chest discomfort, facial edema, and peripheral edema.
Hematomatous swellings associated with prolonged prothrombin times have been reported, but the clinical significance is unknown.
Leukopenia and anemia have been reported in at least one patient. Elevated liver enzymes, elevated bilirubin, and hepatitis have been reported during postmarketing experience.
Cardiovascular side effects have included tachycardia and orthostatic hypotension. EKG changes, including prolonged PR interval, flattened T waves and peaked T waves, have been reported in single cases.
Hypotension primarily orthostatic hypotension has been reported during postmarketing experience. Dermatologic side effects have included pruritus, rash, and urticaria.
Toxic epidermal necrolysis and Stevens-Johnson syndrome have been reported during postmarketing experience. Single dose therapy with ivermectin has been associated with a low rate of serum aminotransferase elevations.
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The block is voltage-dependent and can occur from both sides; either from the intracellular or the extracellular side.
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